However, it also considers such areas as professional practice acts and negligence. The book, however, is not a text on pharmacy law. Rather, it relates the law to the behavior of people, primarily patients and providers of health care. The book is well referenced and draws on legal citations, behavioral studies, and the clinical literature. The liberal use of figures and tables enhances the value of the book as a learning device.
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However, it also considers such areas as professional practice acts and negligence. The book, however, is not a text on pharmacy law. Rather, it relates the law to the behavior of people, primarily patients and providers of health care.
The book is well referenced and draws on legal citations, behavioral studies, and the clinical literature. The liberal use of figures and tables enhances the value of the book as a learning device. The hook is unique in combining the legal aspects of medication with the behavioral aspects. It would be a valuable addition to the library of anyone involved in the drug use process.
Reviewed by Maven J. Edited by J. Dekker, Madison Ave. This book constitutes a collection of 17 papers delivered in London a t the second international symposium on microencapsulation.
The contributors to this hard-covered book are recognized international authorities in the field of microencapsulation. In Chapter 1, the processes of coacervation, spray encapsulation, and nanoencapsulation are reviewed by P. The intricacies of each method are well defined by the author, and applications are also given.
In Chapter 2, A. Watanabe and T. Hayashi describe gelatin-gum arabic coacervation, interfacial polymerization, and the preparation of multiwalled microcapsules, The authors describe the applications of microcapsules in the manufacture of carbonless copy paper, encapsulated perfume ink, and the image display panel, the latter employing the electrophoretic behavior of microcapsules.
The chapter is well illustrated with several photographs and diagrams. In Chapter 3, A. Florence and A. Jenkins deal with the assessment in uitro of microencapsulated drug systems utilized in sustained-release parenteral dosage forms. Drug dissolution, stability, and biodegradability are discussed. The paper is clearly written, well referenced, and illustrated with photographs. Chang, in Chapter 4, reviews the vast amount of research and clinical applications of semipermeable microcapsules used as artificial cells.
Professor Chang, being a leading world authority in this area, is amply qualified to handle this topic, and his paper is documented with 42 references. The applications of microcapsules to augment artificial kidney function are further discussed by R. Sparks et al. A major problem in the microencapsulation of enzymes has been the loss of enzyme activity during the microencapsulation process.
Kondo and N. Muramatsu suggest solutions to this problem in Chapter 5. The use of microcapsules as food particles for marine particulate feeders is discussed by D. Jones and P. Gabbott in Chapter 6. A nylon coat for the microcapsules provided a n indigestable wall to reduce bacterial contact with the enclosed diet. The authors also suggest another important use for microcapsules in the cultivation of marine organisms and that is to supply medicinal compounds, e. In Chapter 7, M. Calanchi describes several new dosage forms containing microcapsules prepared via coacervation.
The author discusses the microencapsulation of antibiotics, aspirin, vitamin C, and steroids and suggests applications of the technique to improve drug stability, overcome incompatibilities, prolong the action of drugs, and conceal the bitter taste of medicinals. Further applications for microcapsules as drug delivery systems, particularly in topical dosage forms, are described in Chapter 10 by R.
In Chapter 8, G. Maggi and F. DiRoberta outline a method used to diagnose and monitor peripheral vascular disorders by employing encapsulated liquid crystal thermography. This chapter should be of great interest to those interested in marketing such products. Further veterinary applications of microencapsulation are outlined in Chapter 12 by G. Chapter 14 should be of particular interest to the biologist.
Kondo et a f. Chapter 15, an excellent chapter by J. Nixon and B. Matthews, deals with the surface characteristics of gelatin coacervate microcapsules using scanning electron microscopy.
Photographs of microcapsules prepared uia alcohol coacervation and sodium sulfate coacervation procedures display definite surface properties, and these differences are discussed in the paper. Further physicochemical studies of microcapsules appear in Chapter Nang and P. Carlier mathematically derive the wall diffusion coefficient and discuss its importance in evaluating microencapsulating methods and the optimization of a coacervation process.
In Chapter 17, the final chapter in the book, L. Luzzi reviews the applications, methods of preparation, and physicochemical properties of microcapsules. The chapter is well written and well referenced.
Discussions of some applications and methodologies, such as coacervation and interfacial polymerization, are redundant in the book; however, due to the multiple authorship, this repetition could be expected. The hook contains an even balance of reviews and original research. I t provides an insight to the science of microencapsulation and should stimulate new research ideas.
The book is not only of interest to the pharmaceutical scientist but is also intended for pharmacologists, biologists, chemists, and veterinary scientists. Reviewed by James W. Practical Pharmaceutical Chemistry.
Third Edition-Part One. Two major additions and several minor revisions have been made in the third edition of this textbook. A new chapter on the registration and assessment of medicines in the United Kingdom has been added. The implications of the Medicines Act of and Good Manufacturing Practices published by HMSO in to the analysts and compilers of product applications is presented in a general manner.
The treatment of general analytical procedures has been extended. This new chapter covers all important product types including tablets, capsules, suspensions, ointments, creams, pressurized aerosols, lozenges, suppositories, solutions, and mixtures as well as dissolution testing, sustained-release preparations, and particle-size control. The suhject matter is presented in 14 chapters.
A limited theoretical treatment is presented, where pertinent, followed by practical examples which have been drawn from the British Pharmacopoeia and other sources.
These examples are intended to serve as laboratory exercises. The book is practical in every sense of the word. I t covers primarily the classical methods of analysis, with discussion of the more sophisticated methods being reserved for Part 2.
Although the style of presentation of determination of equivalent weights is somewhat different than this reviewer is accustomed to, it is very easy to follow.
An insight into the chemistry of many of the limit tests as well as many o f the monographs in the British Pharmacopoeia is provided. Of particular interest to this reviewer were the chapters on chemical purity and control, registration and assessment of medicines, and techniques of quantitative analysis.
These chapters very basically cover the what, why, and how of quantitative analysis, something that is not infrequently overlooked in the education of analysts. Reviewed by Robert E.
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